Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose.

Antipyretic effect of parenteral paracetamol (propacetamol) in pediatric oncologic patients: a randomized trial.

The antipyretic efficacy of propacetamol, an intravenous prodrug of paracetamol, was evaluated in two pediatric prospective randomized studies. In the first, we-compared one standard intravenous dose of propacetamol (30 mg/kg) to one standard intravenous dose of acetylsalicylic acid (ASA, 15 mg/kg) in 10 nononcologic patients with bacterial illnesses. In the second study, we compared two intrav...

a 30 mg/kg loading dose of acetaminophen was more effective than a 15 mg/kg maintenance dose in febrile children.

Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study.

OBJECTIVE To compare the antipyretic benefit of acetaminophen or ibuprofen monotherapy with an alternating regimen of both drugs in young children aged 6 to 36 months. DESIGN Randomized, double-blind, parallel-group trial. SETTING Three primary pediatric community ambulatory centers in central Israel. PARTICIPANTS A total of 464 children aged 6 to 36 months with fever. INTERVENTION Infa...

Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401]

BACKGROUND The antipyretic effectiveness of rectal versus oral acetaminophen is not well established. This study is designed to compare the antipyretic effectiveness of two rectal acetaminophen doses (15 mg/kg) and (35 mg/kg), to the standard oral dose of 15 mg/kg. METHODS This is a randomized, double-dummy, double-blind study of 51 febrile children, receiving one of three regimens of a singl...

Antipyretic Effect of Acetaminophen Versus Ibuprofen in Children Referred to the Pediatric Clinic of Imam Reza Hospital (Mashhad)

Introduction: Acetaminophen and ibuprofen are the most widely used drugs in pediatric medicine to control fever and pain. There are different opinions about the effectiveness, duration of effects, and side effects and duration of action in controlling pain and fever of these drugs. In this study, we decided to examine the antipyretic effects of two common drugs to provide solutions based on the...